I've got PhpED 5.2 running on Vista. I've created an FTP account and have Upload Project avialable but upload files is still greyed out. I want to be able to simply upload a single file to the ftp server. Why is this Upload Files(s) option greyed out? what have I missed?

Figured it out, if I didn't open it from that ftp site, I can't upload it to there...

Is there any way to open a file from one source (say my hard drive) and upload it to another?

Yes, you need to create project first and assign any FTP account to it in Project properties-Publishing.
Then you will be able to Upload files, using Ctrl+Shift+S or even Download it from FTP, by right click on file in Project tree and choosing "Download File(s)". It's really cool feature in PHPEd.